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Component 5: Sleep disturbance is measured via a summation of 9 indicators which have the same root, "During the past month, how often have you had trouble sleeping because you..." and response options of (0) Not during the past month, (1) Less than once a week, (2) Once or twice a week, and (3) Three or more times a week: "Wake up in the middle of the night or early morning", "Have to get up to use the bathroom", Cannot breathe comfortably, Cough or snore loudly, Feel too cold, Have bad dreams, Have pain, and Other reason(s), please describe:

Especially when we start to train AI models on these type of data

10.1371/journal.pone.0078774 13 ArrietaM

This systemic approach aligns with holistic perspectives on vitality that recognize the interconnectedness of all bodily systems

, MD Hospital Medicine, Vaccines, Infections-Respiratory Vanderbilt Children's Infectious Diseases 2200 Children's Way 6th Floor Nashville, TN 37232 6153222250 Vanderbilt Monroe Carell Jr

This extrapolation involves two critical decisions: (1) selecting a point of departure (POD), which corresponds to the lowest dose associated with observable adverse effects within the range of data from a study, and (2) selecting the mathematical model used to extrapolate risk from typical human exposures that are well below the POD