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For T0901317 experiments, mice were injected intraperitoneally with either vehicle (10%DMSO in 90% corn oil) or T0901317 (MedChem Express, HY-10626) at a dose of either 16.9 mg/kg or 50 mg/kg dose for either 4 days (1720) days post AAV-TBG-Cre treatment) or 14 days (720) days post AAV-TBG-Cre treatment)

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H2O2 can be converted into highly reactive hydroxyl radicals (OH-) by the Fenton reaction, and can cause lipid peroxidation. More info about superoxide can be found here In properly functioning cells, superoxide dismutase (SOD) converts superoxide into hydrogen peroxide (H2O2) and water

256,257 To maintain the cellular NAD + level, NAD + salvage enzyme NAMPT has been activated by LPS to boost the salvage pathway

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