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Meanwhile, another study also confirmed that the intervention of donepezil combination therapy reduced doxorubicin-induced neuroinflammation and cerebral oxidative stress as well as restored mitochondrial homeostasis without altering the anticancer properties of doxorubicin in the breast cancer phenotype [167]

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Zolty R

In conclusion, lipid accumulation plays multiple roles in the pathogenesis of renal tubular injury of DKD, including impairing tubular cell function, increasing oxidative stress and mitochondrial dysfunction, inducing inflammation, promoting tubular cell death and exacerbating hypoxia

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