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Indeed, GSH-depleted mice demonstrated a higher level of hepatic insulin action (Figure 1L), and increased whole-body glycogen synthesis (Figure 1M), supporting enhanced insulin sensitivity as a consequence of GSH depletion

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.,HouN,ToriiS,SaitoN,HosakaMTakeuchiTReactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases.2008;149(4):16541665

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