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Kang and Kramer, 2000

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Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial

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Combined with a low-fat diet, 5-Amino-1MQ treatment rapidly normalized body weight and adiposity to levels matching age-matched lean animals, an outcome that diet alone could not achieve in the same timeframe