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Increased G6PD activity appears to meet the demand of NADPH for cell proliferation and for combating oxidative stress

Many weight-loss interventions cause significant muscle loss alongside fat loss, which can slow metabolism and make weight maintenance difficult

Janzen, V

Recent research suggests that metformin may also alter the gut microbiota, through the protection of the intestinal barrier, promotion of SCFAs producing bacteria growth, regulation of bile acids plasmatic levels and their excretion, and direct regulation of growth of bacteria with a positive effect on glucose homeostasis (eg., Akkermansia muciniphila ) (Zhang and Hu, 2020)

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