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The NNT encoded enzyme utilizes the energy of the mitochondrial proton gradient (the proton motive force) to catalyze hydride transfer from NADH to NADP + generating NADPH

In particular, the cystine/glutamate antiporter (System X c ), glutathione peroxidase 4 (GPX4) and glutathione (GSH) (System X c /GSH/GPX4 axis) plays a key role in preventing lipid peroxidation-mediated ferroptosis, because of which could be inhibited by blocking System X c /GSH/GPX4 axis

Although known as a cuprous oxidase, CueO prevents this interaction by directly oxidizing catechols such as dihydroxybenzoic acid, an enterobactin biosynthetic precursor (Grass et al., 2004)

Updated 2024-11-07

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doi: 10.1111/nyas.2019.1446.issue-1 11 Joint FAO/WHO Expert Committee on Food AdditivesInternational Program on Chemical Safety