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QSP modeling of a transiently inactivating antibody-drug conjugate highlights benefit of short antibody half life

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[PUBMED Abstract] Kirkwood JM, Strawderman MH, Ernstoff MS, et al.: Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684

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Shaking introduces harsh mechanical forces (shearing) that can physically break these chains apart, denaturing the peptide and rendering it inactive for your research

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