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not FDA-approved and used only in a research context

J Atheroscler Thromb 17:111 Chen S, Zhang W, Tang C, Tang X, Liu L, Liu C (2014) Vanin-1 is a key activator for hepatic gluconeogenesis

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Inhibition of aldose reductase (AR), either alone or in combination with chemotherapeutic drugs, has evolved as a pragmatic therapeutic option for cancer