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This multi-pathway approach aligns with research published in the International Journal of Molecular Sciences showing GHK-Cu stimulates collagen, elastin, and glycosaminoglycan synthesis simultaneously

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Increases in proinflammatory cytokine such as TNF, IL-4, IL-6 and IL-13 have all been shown to increase epithelial permeability and have been tied to increased expression of claudin-2 in animal and human models as well as decreased expression of JAM-A and occludin [152, 153]

Ciba Found Symp 1986;118:102126