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Description
In this paper, we present a new integrated model for hepatic glutathione metabolism including one-carbon metabolism and use it to investigate how the activation of certain enzymes by estradiol in one-carbon metabolism and glutathione metabolism leads to dramatic changes in reaction velocities and metabolite concentrations, including GSH and the GSH synthesis rate
ACLY inhibitors induce apoptosis and potentiate cytotoxic effects of sorafenib in thyroid cancer cells
132 , e162123 (2022)
Key astrocyte-derived factors include C-X-C motif chemokine ligand (CXCL10), stromal-derived factor 1 (CXCL12), Fas ligand (FasL/CD95L), TNF superfamily member 10, TNF-related apoptosis-inducing ligand 2 (TRAIL), high mobility group B1 protein (HMGB1), A and lipocalin-2 (LCN-2)
However, their potential to induce drug-drug interactions remains underexplored
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