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Finally, among the substances identified based on the market analysis, most of them showed an ambiguous status, which may render these findings difficult to incorporate into practice

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TMAO increases trans-differentiation of human primary renal fibroblasts into myofibroblasts in conjunction with TGF-1 signaling Based on TMAOs detrimental association with kidney damage of diverse aetiologies 19,20 similar to renal fibrosis 46 , we investigated the impact of TMAO on human primary renal fibroblasts (HRFs)

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