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While QIIME-like frameworks are best for reproducible and interpretable surveys, deep learning models provide strong predictive power but require careful validation, and metabolic modeling uniquely links microbial alterations to host functional pathways

The major challenge is to balance activating CICD pathways without inducing harmful responses, such as inflammation, immune evasion, and therapy resistance (Zhao et al

Impact of bioelectrical impedance-guided fluid management and vitamin D supplementation on left ventricular mass in patients receiving peritoneal dialysis: a randomized controlled trial

Apr 2016;87(4):367-72

Arch Ophthalmol 124:14571462

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