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Still, they are also a result of mitochondrial dysfunction, which occurs when mitochondria lose the protection of GSH, free radicals attack the mitochondria, and cellular energy decreases.8 Autoimmune conditions like multiple sclerosis, Crohns disease, rheumatoid arthritis, diabetes, Lyme disease, heavy metal load, organotoxins, and more all have mitochondrial dysfunction, low levels of GSH, and profound fatigue

While HepG2 cells treated with NaOX were unaffected by etomoxir, inhibition of CPT1 in control cells significantly reduced the oxygen consumption rates to a level comparable with cells treated with oxalate (Fig