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Although the incidence is lower than other more common irAEs, it has a poor prognosis and often results in delay or discontinuation of ICIs

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Macrophage plasticity and atherosclerosis therapy

( B and C ) 4T1 tumorbearing mice were treated with vehicle or JHU083 alone, or vehicle or JHU083 in combination with 250 g anti-PD1 and 100 g of anti-CTLA4 antibodies (on days 7, 10, 13, 17, and 24)

[DOI] [PubMed] [Google Scholar] 100.Attrill GH et al

10.1016/j.cell.2012.03.042 24 DollS.FreitasF
