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Additionally, total protein, albumin, and globulin levels may have some influence on MTXs clearance because of its about 50% protein binding rate (Mei et al
2008;3:e3815
In the article by Hoffer [1] it was reported that NAC treatment was supplemented, in some patients, with standard treatment with topiramate, a non-narcotic medication used to treat post-traumatic headache symptomatically
In addition to substrate binding, the NPEY motif in both IR and IGF1R is known to be involved in receptor internalization (20, 22)
This approach ensures that both patients and healthcare providers are well-informed about potential risks and can take measures to mitigate them
Histological assessment and scoring were performed by a pathologist blinded to the study conditions
