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It may also lead to more serious side effects

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The chamber depths were chosen such that the oxygen concentration ranged from approximately 415% (Mazzei et al., Adenosine Triphosphate (ATP) Cell Viability Assay ATP cell viability assay was performed using CellTiter-Glo Luminescent Cell Viability Assay (Promega) following manufacturer's instructions

doi: 10.1073/pnas.0400282101

However, excess glutamate levels suppressed hepatic glutamine synthetase activity, thereby impairing the ammonia detoxification capacity and inducing pathological hyperammonemia