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Growth and maturation of the autophagosome is mediated by the Atg5Atg12 pathway and by the microtubule-associated protein 1 light chain 3 (LC3, the mammalian homolog of yeast Atg8) pathway, both of which depend on Atg7 (Honda et al., 2014)

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WKS is characterized by acute encephalopathy progressing to chronic impairment of short-term memory