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Current treatment strategies for patients with PitNETs are aimed to control biochemical activity and reduce tumour size while maintaining normal pituitary function or entirely remove the tumour via surgery [7]

GPX1 is ubiquitous in cytoplasm and mitochondria, formerly known as cytoplasmic GPX (CGPX), is the first discovered member of the GPx family, almost all cell mitochondria and cytoplasm can be detected, it is also one of the most widely expressed and highest content of selenoproteins in the human body (Alehagen et al., 2021), its main role is to catalyze glutathione (GSH) to reduce toxic peroxides in the body, including hydrogen peroxide, cholesterol peroxide and long-chain fatty acid peroxide (Alehagen et al., 2021
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Rahmanabadi et al

This suggests that sesamin directly quenched ROS and alleviated oxidative burden, making an extreme upregulation of catalase unnecessary
