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Increased mRNA expression of osteoprotegerin (OPG), while decreased receptor activator of nuclear factor kappa B ligand (RANKL) mRNA expression, resulting in an increased OPG/RANKL ratio.\nSignificantly increased mRNA expression of BMP2, runt-related transcription factor 2 (Runx2), and osterix (Osx) in a dose-dependent manner

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In a study conducted by Tsacopoulos et al

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