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[] Lecithin-cholesterol acyltransferase (LCAT), also a hepatokine, mediates the crosstalk between the liver and the bone in the pathogenesis of hepatic osteodystrophy (HOD, a metabolic bone disease in patients with chronic liver diseases, e.g., alcoholic liver disease, NAFLD and NASH, primary sclerosing cholangitis, primary biliary cirrhosis, viral hepatitis, viral cirrhosis, Wilson disease, and hemochromatosis)

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