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glutathione redox buffer Frontiers is made up of highly conserved domains such as two Rossmann fold domains Glutathione in Cellular Redox Homeostasis:
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Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig

This process is mainly regulated by glutathione peroxidase 4 (GPX4), which neutralizes lipid peroxides, and the Xc- system of cystine/glutamate antiporters, which maintains intracellular glutathione (GSH) levels [4]
& Wen, J

Int J Mol Sci 21: 3550, 2020

Combined with albumin binding through the fatty acid chain (which buries the N-terminus during transport), the result is extended stability in plasma protein binding assays while retaining high receptor selectivity
