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Textoris J, Beaufils N, Quintana G, et al

When ER stress is excessive or prolonged beyond the adaptive threshold, UPR signaling can shift from cytoprotective to pro-apoptotic outcomes, frequently through crosstalk with mitochondrial death pathways

However, despite this increase in its precursor, betaine levels seemed to have been insufficient to meet the increased demand for methyl-group donors in COC users

Moreover, properly harnessing the Nrf2/HO-1 axis while managing its potential pro-ferroptotic risks may help maintain redox balance and curb iron overload, thereby offering an additional strategy to alleviate ferroptosis-driven damage in OA (202)

In a depressive-like monkey model, significant changes in the gut microbiota were observed, and lipidomic analysis revealed abnormal lipid metabolism in brain regions (171)

PVP powder was added to a predetermined volume of water and mixed using a magnetic stirrer