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[DOI] [PubMed] [Google Scholar] Hertog MG, Hollman PC, Katan MB, Kromhout D

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5-Amino-1MQ acts as a competitive inhibitor with respect to the nicotinamide substrate (submicromolar IC50), increasing the intracellular nicotinamide available for NAD+ salvage via NAMPT - which is then studied for downstream effects on NAD+-dependent sirtuins and mitochondrial function