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With regard to the alternative bile acid biosynthetic pathway, bile acids can signal via FXR-MAFG to repress expression of important biosynthetic genes such as CYP27A1 and CYP7B1

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We expect our findings will reveal unique plant cell polarity domains along with details about their establishment and maintenance, identify novel PLK functions, and, ultimately, uncover mechanisms underlying repression of cell division with potential translational and therapeutic value

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No human clinical trials have been conducted outside of Russia as of this writing