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1 Some sleep disorders precede diagnosis, acting as harbingers of PD

This residue is followed in most enzymatically active Grx by a proline, a tyrosine and a second cysteine residue in a CPYC-motif, whereas a glycine, a phenylalanine and a serine residue are usually found in a CGFS-motif in inactive Grx

However, as reassuring as all of this is, there are a couple of things to remain mindful of: Copper toxicity Because GHK-Cu contains copper, it does pose a potential risk of copper toxicity,12 the symptoms of which include abdominal pain, vomiting, chest pain, chills, cough, fever, general weakness, anemia, burning sensations, tremors, and a metallic taste in the mouth.13 The risk is small, as the concentrations of copper in the peptide are typically well within safe parameters, but its good to be aware of it

J Neurosci Res 80:655666 Woehrling EK, Hill EJ, Coleman MD (2007) Development of a neurotoxicity test-system, using human post-mitotic, astrocytic and neuronal cell lines in co-culture