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Furthermore, increased copper levels can increase reactive oxygen species (ROS) production and activate the NF-B signalling pathway, exacerbating inflammatory changes within the vascular wall and promoting atherosclerosis (25)

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The identification of reliable validated biomarkers could facilitate earlier and more accurate diagnosis and drive the development of targeted pharmacological therapies that might address the underlying pathophysiology of these diseases

In Japan, a deficiency is found in levels under 550 pg/ml (400pM)

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They may be, peripherally, marked heart congestion and large areas of subendocardial ischemic (pyknotic) myocytes, lung (hemorrhage), liver congestion and kidney congestion, gastrointestinal lesions, portal and caval hypertension and aortal hypotension