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Cystinosin deficiency leads to impaired lysosomal clearance and disrupted endolysosomal trafficking, which in turn contributes to defective autophagy and altered proteostasis [144, 146, 147]

We also observed decreased GSH in BP compared to CON (CON, 1.7361.766

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& Burr, M

2024;2:529550 DOI: Received: June 18, 2024 Accepted: September 12, 2024 Published: October 22, 2024 Academic Editor: Ken Ohta, Japan Anti-Tuberculosis Association (JATA) Fukujuji Hospital, NHO Tokyo National Hospital, Japan This review delves into the complex role of 12/15-lipoxygenase (12/15-LOX) in asthma pathogenesis, focusing on its contributions to mitochondrial dysfunction, oxidative stress, epithelial injury, and airway remodeling

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