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[13] [14] In higher plants, SOD isozymes have been localized in different cell compartments

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Therefore, in response to glucagon, hepatic glucose production increases , helping the liver counteract the drop in blood glucose levels

Collectively, these results highlight the ability of highly engineered apocynin derivatives to specifically inhibit the NOX2 isoform at its mitochondrial source, while substances such as GKT137831 support the more general NOX inhibition strategy to reduce vascular and tissue-specific ROS in fibrotic diseases and diabetic nephropathy