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This was further supported by another study that documented combination of genistein and daidzein induced downregulation of perilipin-1, Tip-47, and adipose differentiation-related protein family proteins leading to inhibition of lipid droplet accumulation and induction of apoptosis in HT-29 colon cancer cells ( Thus, in view of outlined scientific literature, genistein has been extensively documented to induced cancer cell apoptosis via different signaling cascades from activation of caspases to induction of ER stress, oxidative stress, MAPK, and PPAR pathway

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Moreover, western blot analysis indicated that the protein levels of Nrf2 in the nucleus were increased in cells treated by (+)-CLA (Fig

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5.3.2 TIM-3 TIM-3 is linked to T cell exhaustion and defective immune regulation in asthma (143)

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All authors have approved the final version of this manuscript

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