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The addition of glutathione makes the toxic compounds more water-soluble and thus able to be excreted in urine or feces.[ref] GSTM1 enzyme: This enzyme helps the body detoxify several types of carcinogens, drugs, toxins, and oxidative stress byproducts

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Molecules 27(24):8899

Another key point to assess is that murine models treated in this study were affected by liver-only metastases, with the liver being a particularly GSH-rich organ, that may represent a bias for evaluating this combination as an effective response in clinical practice, considering that melanoma metastases may occur in every other organ

The use of proton magnetic resonance spectroscopy and mass spectroscopy techniques focused on GSH detection in tumors, particularly as an indicator of treatment efficacy and success, taking advantage of the high flux of GSH in and between tumor cells and their microenvironment

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