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N -Methylation of Compounds 1.70 and 1.71 was achieved using the steps outlined in Figure 2 on resin using 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU)

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Simultaneously, additional reactions unfold, giving rise to toxic substances like hypochlorous acid (HOCl), further amplifying the macrophages arsenal in the ongoing cellular warfare ( Concomitantly, the macrophage orchestrates the induction of inducible nitric oxide synthase (iNOS)