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In 2008, Marcus Conrad and his colleagues reported that genetic inactivation of GPX4 induced a non-apoptotic cell death driven by lipid peroxidation that could be suppressed by alpha-tocopherol (Seiler et al., 2008), and that overexpression of xCT protected cells from lipid-peroxidation-induced non-apoptotic cell death (Banjac et al., 2008)

otorhinolaryngology 76 (9), 13431346

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Similar content being viewed by others Introduction Neurodegenerative diseases, such as Parkinsons (PD) and Alzheimers (AD), are largely due to neuronal damage often triggered by oxidative stress 1,2

[DOI] [PubMed] [Google Scholar] 48.Mao P., Reddy P

J Affect Disord 136:933939 Mahmoudi M, Bayat AH, Boroujeni ME et al (2019) Curcumin protects purkinje neurons, ameliorates motor function and reduces cerebellar atrophy in rat model of cerebellar ataxia induced by 3-AP