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Preclinical studies and clinical trials evaluating CD38 inhibition are ongoing in patients with either solid tumors or hematological malignancies, including MM ( 2.4 CD38 enzyme activity and therapeutic antibodies: potential influence on refractoriness A crucial question is whether the binding of therapeutic CD38 antibodies interferes with the enzymes functional activity

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Anti-CD38 antibody therapy: windows of opportunity yielded by the functional characteristics of the target molecule

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Research Mechanism (Mechanism of Action) NNMT normally catalyses the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA)