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28 In 1977, Shiro Bannai and colleagues observed that withdrawal of cystine-induced cell death accompanied by glutathione (GSH) depletion could be rescued by antioxidant vitamin E supplementation

NAADP induces the lysosomal Ca 2+ efflux and calcineurin-mediated TFEB activation, which enhances the expression of pro-inflammatory cytokines including IL-1, IL-1 and IL-6

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