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Figure 1 2.5 Cognitive performance and sustained cognitive effort (task performance during MRI) In the Rule switching flexibility task (adapted from Sekutowicz et al., 2016

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Oral adenine is classified as acutely toxic and is often used to induce chronic kidney disease in rodents, caused by the catabolism of adenine into 2,8-dihydroxyadenine that crystallizes in renal tubules 69