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Critical Considerations and Potential Downsides It would be irresponsible to discuss the potential synergies without an unflinching look at the complexities and risks involved in such research

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For example, through NF-B induction, TNF- inhibits the expression of peroxisome proliferator-activated receptor gamma coactivator- 1 (PGC-1), which plays critical role in SIRT1 signalling

Diosgenin can regulate BAs metabolism through the liver FSR-shp and intestinal FSR-FGF15 pathways, especially in the CA, TCA, and treat NASH (Yan et al., 2023)

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