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This extended inhibition window is why once-daily dosing works, but it also means the initial timing sets the metabolic tone for the entire 24-hour cycle

It has even been proposed that NNMT be considered as a novel and sensitive serum biomarker for detecting colorectal cancer, outperforming the clinical significance of carcinoembryonic antigen (CEA) (42)

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High expression of nicotinamide N-methyltransferase in patients with obesity and insulin resistance

It is essential to weigh the benefits against any potential concerns you may have
