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This work provides compelling evidence for the physiological relevance of MOR biased signalling, as comparing biased signalling with behavioural effects of a range of MOR agonists reveals strong correlation between G i /-arrestin bias factors and the analgesiarespiratory depression therapeutic window

Acta 539, 121026

The parents were exposed to this concept by reading popular books on the topic of total allostatic load and autism [158], listening to autism-focused audio materials [156] provided by their coach, and subsequently taking the Child Health Inventory for Resilience and Prevention (CHIRP) survey of the Documenting Hope Project, a comprehensive assessment of total allostatic load among children [161]