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(2003) Randomized, placebo-controlled trial of intramuscular vitamin B12 for the treatment of hyperhomocysteinaemia in dialysis patients

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Some of the earliest work suggesting that NAD + affects macrophage function showed that inhibition of NAMPT and subsequent depletion of NAD + pools in macrophages decreased the secretion of proinflammatory cytokines, such as TNF, and caused morphological changes, such as reduced spreading in these cells 100,101

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[2] Campagna, R., et al