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Glutathione (GSH) GSH, a naturally occurring antioxidant, plays a vital role in protecting cells from oxidative stress-induced damage, regulating DNA expression, detoxifying reactive metabolites, providing cysteine reservoirs, modulating apoptosis and antigen-presenting cell functions [92]

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However, despite the anti-diabetic and anti-obesity functions, of these dual and triple agonists, the long-term safety, cardiovascular, and renal benefits of these multi-target therapies need further validation