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doi: 10.1073/pnas.0502552102

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Zeng L, Zampetaki A, Margariti A, Pepe AE, Alam S, Martin D, Xiao Q, Wang W, Jin ZG, Cockerill G, Mori K, Li YS, Hu Y, Chien S, Xu Q

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The major product of ALA incubation with 15-LOX-1 is 13-HpOTrE, which is further reduced to 13-HOTrE

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Polyphenol-mediated epigenetics regulated by oxidative stress Oxidative stress is a pivotal factor influencing epigenetic mechanisms, which play significant roles in the pathogenesis of neurodegenerative diseases [127, 149, 150]

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However, compounds that modulate ferroptosis by influencing lipid peroxidation are predominantly confined to the ER, implying the pivotal role of the ER in lipid peroxidation during ferroptosis (88)

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Rounded outliers lie in the range of 1.53 times the height of the box and asterisks or stars are extreme outliers that have values more than three times the height of the boxes

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