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Heavy metals, such as lead, mercury, and cadmium, can deplete glutathione levels, impairing the body's ability to detoxify harmful substances and reducing the availability of SAMe for methylation

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Notably, the effects of disrupting apoplastic ascorbate are consistent with frequently observed effects of antioxidant application: bigger plants through increased cell expansion and response to auxin, more stress-tolerant plants through SA signaling, and changes to endogenous antioxidant levels

doi:10.1001/jama.288.16.2023 [6] Lewis SJ, Ebrahim S, Davey Smith G

Phenolic compounds and their antioxidant activity in plants growing under heavy metal stress

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