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The damage landscape The damage landscape is dictated by both the ROS species and their location: in lipids, H 2 O 2 -initiated or OH-driven peroxidation generates reactive aldehydes that crosslink proteins and disrupt membrane architecture (Liu et al

2025;77:e70036

10.1016/S0141-0229(02)00038-8 Enzyme Microb

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3,17 Less frequent phlebotomy therapy may be necessary in some patients who cannot tolerate weekly treatments

This review will be of great interest to those working in materials science, nanotechnology, and especially to those in biomedical engineering and translational medicine, which will not only serve as an up-to-date compilation of achievements in this area, but also provide a generalized guideline for BBB regulation and rational design of targeted drug delivery systems