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Poncirin and its metabolite ponciretin attenuate colitis in mice by inhibiting LPS binding on TLR4 of macrophages and correcting Th17/Treg imbalance

These naturally occurring substances-such as polyphenols (e.g., curcumin, resveratrol), omega-3 fatty acids (e.g., DHA, EPA), and sulforaphane from cruciferous vegetables exert antioxidant, anti-inflammatory, anti-apoptotic, suppression of ferroptosis, and neuroprotective effects that help limit secondary brain damage and support neural regeneration

D.BassettP.AbbaraA.et al (2023a)

The common pathogenic feature in these disorders is microvascular lesions that result in luminal narrowing, often due to the deposition of thrombi, producing shear stresses that mechanically injure passing red cells

Despite the known link between PsO and PsA, reliable biomarkers for predicting PsA onset remain elusive