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It works as a potent antioxidant, improves blood flow to nerves, and enhances glucose uptake all of which can help reduce burning, tingling, and pain associated with neuropathy.1 Clinical trials have shown consistent benefits at 600mg per day, particularly when taken long-term and under medical supervision.7 Benfotiamine (300mg per serving) Benfotiamine is a fat-soluble form of vitamin B1 (thiamine) with significantly better bioavailability than standard thiamine.46 It plays a central role in glucose metabolism and helps prevent the accumulation of harmful byproducts like advanced glycation end products (AGEs), which contribute to nerve damage in diabetes

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Silymarin exerts its antioxidant effects in vitro not only by blocking NS5B polymerase activity, but mainly by inhibition of viral entry, stabilizing the membranes and yielding them less prone to fusion

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SIRT3, found in mitochondria, needs NAD+ to work

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