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Gancher, S

ROS affecting the activity of a plethora of TFs eventually leads to changes in chromatin modifications and subsequent epigenetic reprogramming 33

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As shown in Figure 9A , confocal microscopy with phalloidin staining revealed disrupted cytoskeletal architecture, with actin ringsstructures essential for bone adhesion and resorptionbeing absent or severely disorganized in HIV-exposed cells (see also Supplementary Figures S4A, B )