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Therapeutic Peptides Targeting PPI in Clinical Development: Overview, Mechanism of Action and Perspectives

2C and Supplementary Table 1)

Although species differences and dosing regimens vary, the overall direction of the biochemical effect remains consistent across models

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As explained above, the vessel co-option acts as an important mechanism of resistance to anti-angiogenesis as well as an important source of blood supply that supports the growth of tumors

Although cells have mechanisms to repair such errors, increased levels of ROS combined with impaired repair mechanisms can lead to cell death [123]