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However, despite the compensatory increase in NADPH levels and the decrease in superoxide production, G6PD-deficient myocardium had increased oxidative stress in response to pressure overload as indicated by a decrease in GSH, indicating an adverse effect of G6PD deficiency

doi: 10.1128/JCM.03529-13 25 BentleyS

The ACE2 is a protease that participates in the renin-angiotensin system (RAS)

Harper, S., & Speicher, D
