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In such conditions, the APX-MDHAR system could work largely as a closed cycle, with minimal or minor input from glutathione (Fig

This method has been used to detect persulfides directly in-gel or in cells and whole organisms by microscopy, to perform antibody microarray analysis of persulfidated targets, and for persulfidome analysis by MS (Aroca et al., 2021

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Statistical analysis For animal studies, sample sizes ( n = 5 per group, 3 in the tirzepatide-treated group) were determined based on prior in-house experience and previous studies using similar mouse models to ensure adequate power to detect biologically relevant effects

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High intake of vitamin B12 alone was not associated with increased risk